This clinical study has started in the in the 3rd hospital of Guangzhou Medical University. It is designed to evaluate safety and efficacy of a novel CAR-NK cell therapy for patients with an advanced cancer. The study is titled: Pilot study of NKG2D-ligand targeted CAR-NK cells in patients with metastatic solid tumours, and it is registered in the ClinicalTrials.gov.:https://clinicaltrials.gov/ct2/show/NCT03415100?term=NCT03415100&rank=1 。
NK cells are a type of immune cells capable killing tumor cells via natural cytotoxicity. CAR-NK refers to engineering Chimeric Antigen Receptor into NK cells in order to target a tumor-associated antigen. CAR-NK offers a promising adoptive immunotherapy for treating cancers. Converd's trial aims to extend this approach to develop clinically applicable CAR-NK therapy for metastatic cancers.